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L-asparaginase is a bacterial enzyme isolated from Escherichia coli and Erwinia carotovora. The enzyme from this latter has some advantages (less risk of causing allergic reactions) and some disadvantages (reduced activity and often difficult to obtain). There is also a pegylated form (PEG-asparaginase), which is the enzyme extracted from E. coli stabilised by polyethylene glycol. PEG-...
An adult (18-month-old) dog was presented for lameness and bleeding of the paws of 4 months’ duration. The owner reported that the lesions developed slowly, and only recently did all four paws look similar to the one shown (96). The paws were painful, swollen, and exudative. The interdigital tissue was friable, and blood and pus exuded from the area when it was touched.
Abortion means the spontaneous or induced interruption of a pregnancy with expulsion of the products of conception. A pregnancy can be interrupted at various points in its evolution and can be followed by embryonic reabsorption or expulsion of foetuses at different stages of development, dead, with or without lysis, maceration or mummification, or in some cases alive but incapable of ex utero...
Acquired laryngeal paralysis (LP) may be related to trauma, neoplasia, polyneuropathies or hypothyroidism. However, the idiopathic form is the most common diagnosis. Medical management with sedatives, oxygen supplementation, cold environment, rest and steroids, when needed, can temporarily alleviate clinical signs.
Hyperparathyroidism is an endocrine disorder characterised by an excessive synthesis and secretion of parathyroid hormone (PTH) by the chief cells of the parathyroid glands. The disease can be primary or secondary. In primary hyperparathyroidism (PHPTH), the hypersecretion of PTH is caused by an adenoma or, more rarely, by a carcinoma of the parathyroid chief cells. In the primary form, the...
Diabetes mellitus is undoubtedly one of the most frequent endocrine disorders in the dog and cat. Diabetes is a disease characterised by hyperglycaemia resulting from insulin deficiency and/or resistance; it is the consequence of absolute or relative insulin deficiency, caused, in turn, by an inefficiency of the beta cells of the endocrine pancreas. The clinical manifestations are mainly linked...
Renal secondary hyperparathyroidismis a metabolic disorder that affects about 75% of dogs and 84% of cats with chronic kidney disease (CKD). Numerous factors are implicated in the pathogenesis of this endocrine abnormality (Fig. 1): retention of phosphorus secondary to a decrease in glomerular filtration rate and reduced synthesis of 1,25-(OH)2D constitute the initial stimulus to increase the...

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